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Dec 11, 2025 4:00 PM

Rhythm Pharma Strikes Chord As Early PWS Trial Results Show Promise

Rhythm Pharmaceuticals Inc. (NASDAQ:RYTM) stock is higher on Thursday, after the company shared preliminary results from its exploratory Phase 2 trial of setmelanotide in patients with Prader-Willi syndrome (PWS).

PWS is a rare genetic disorder characterized by muscle weakness and feeding difficulties in infancy. An insatiable hunger and tendency toward severe obesity starting in childhood could follow.

PWS also involves delayed development, intellectual disability, behavioral issues, and physical traits, such as short stature.

Rhythm enrolled 18 patients. The 52-week trial remains ongoing.

Setmelanotide therapy demonstrated potential therapeutic benefit with BMI and hyperphagia (extreme hunger) reductions in patients with PWS ...