Novartis Says Conditionally Approved Kidney Drug Shows Long-Term Promise

On Friday, Novartis AG (NYSE:NVS) shared final results from the Phase 3 ALIGN study supporting a slowing decline in kidney function in adults with IgA nephropathy (IgAN) who were treated with Vanrafia (atrasentan).

IgAN (Berger's disease) is a chronic autoimmune kidney disease caused by the buildup of immunoglobulin A (IgA) protein in the glomeruli, causing inflammation and reducing the kidneys’ ability to filter waste.

Vanrafia received accelerated approval in the U.S. and China for the reduction of proteinuria in adults with IgAN in April 2025. After the trial data, Novartis plans to submit for traditional approval in 2026.

In April 2025, the company said it had not been established whether Vanrafia slows kidney function decline in patients with ...

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Novartis Says Conditionally Approved Kidney Drug Shows Long-Term Promise

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