Oklo Inc. (NYSE:OKLO) shares came under pressure on Wednesday after the company reported weaker-than-expected earnings, even as it highlighted progress on a key regulatory milestone.

Earnings Snapshot

Oklo reported a loss of 27 cents per share for the fourth quarter, missing analyst estimates for a loss of 16 cents per share, according to Benzinga Pro.

The pre-revenue company reported operating losses of $139.3 million in 2025. Oklo said it expects substantial, ongoing operating costs as it builds out powerhouses and fuel fabrication facilities, secures fuel supply, and scales its radioisotope business.

Oklo said it expects total cash used in operating expenses for 2026 to be in the range of $80 million to $100 million and total cash used in investing activities to be in the range of $350 million to $450 million.

DOE Approval And Growth Outlook

Alongside the earnings release, Oklo said the U.S. Department of Energy approved its Nuclear Safety Design Agreement for Atomic Alchemy's Groves Isotopes Test Reactor in Texas under the DOE's Reactor Pilot Program.

“With DOE’s approval, we are making meaningful progress in the development ...